DIHsP4_Medicine is a consortium of 4 Digital Innovation Hubs from four European regions: Madrid, Ljubljana, Auvergne-Rhône-Alpes and Nord-Vest of Romania, which aim to address the necessary steps to build successful collaboration mechanisms among DIHs focused on health sector. Digital transformation of this field has a high level of technical complexity, and therefore requires the intervention of a wide range of stakeholders. Lessons learned from this project will be useful for building future corridors, or similar collaborative ecosystems that involve the participation of highly specialized players.